Interleukin-1 a, Interleukin-1/?, and Tumor Necrosis Factor Gene Expression in Endotoxin-Induced Uveitis
نویسندگان
چکیده
Results. Little expression of IL-la, IL-1/3, and TNF genes was observed in normal ICB. IL-la gene expression began to increase (about 10-fold greater than that of the control) as early as 1 hour after the LPS treatment, reached a peak (about 100-fold) at 3 to 6 hours. A second peak (60-fold) was observed at 24 hours, and the expression returned to near basal levels (3-fold) at 48 hours. Expression of IL-1/3 and TNF genes showed a pattern similar to that of IL-la. Three hours after LPS treatment, IL-1/3 and TNF genes were found by in situ hybridization histochemistry to be expressed by "histiocyte-like" cells in the stroma of the ICB. None of these genes were detected in the control rats.
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